83-46-5 beta-Sitosterol AKSci 0140AP
 
 
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  0140AP    AKSci Technical Grade
beta-Sitosterol
, 44% (GC) with Campesterol (~24%), Stigmasterol (~28%)
 



IDENTITY
CAS Number:83-46-5
MDL Number:MFCD00003631
MF:C29H50O
MW:414.71
EINECS:201-480-6
BRN:1916165
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:44% (GC) with Campesterol (~24%), Stigmasterol (~28%)
Physical Form (at 20°C):Solid
Melting Point:136-142°C
Optical Rotation:-33° - -39° (c=0.5, CHCl3)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Phytosterols

REVIEW

 Beta-Sitosterol is one of several phytosterols related to cholesterol. It reduces blood levels of cholesterol by competing with it for absorption in the intestine and is sometimes used in treating hypercholesterolemia. Due to its structural similarity to cholesterol, when sitosterol is absorbed in the intestine, it is transported by lipoproteins and incorporated into the cellular membrane. It takes the place of dietary and biliary cholesterol in micelles produced in the intestinal lumen.

REFERENCES
[1]Geoffroy, Philippe; Julien-David, Diane; Marchioni, Eric; Raul, Francis; Aoude-Werner, Dalal; Miesch, Michel Synthesis of highly pure oxyphytosterols and (oxy)phytosterol esters Steroids (2008), 73(7), 702-707.
[2] Hang, Jiliang; Dussault, Patrick A concise synthesis of beta-sitosterol and other phytosterols Steroids (2010), 75(12), 879-883.
[3] Berges RR, Windeler J, Trampisch HJ, Senge T. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet. 1995 Jun 17;345(8964):1529-32.
[4] Wilt TJ, MacDonald R, Ishani A.beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int. 1999 Jun;83(9):976-83.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of June 25, 2024

AKSci Technical Grade compounds are suitable for commercial and industrial applications, and in areas where official standards may not yet exist.


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CATEGORIES

 APIs and Bioactives > Hypercholesterolemia


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