[84680-54-6] Enalaprilat dihydrate AKSci X2108
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  Catalog ID # X2108
Enalaprilat dihydrate
, 98% (ELSD)

CAS Number:[84680-54-6]
MDL Number:MFCD00941393
Purity:98% (ELSD)
Available Spectra:LCMS, FT-IR, HPLC
Physical Form:White crystalline powder
Melting Point:151-159°C
Long-Term Storage:Store long-term at -20°C
Shipping:Not Regulated for Shipping

Solubility:DMSO: 70mg/mL; H2O: 5mg/mL; EtOH: 1mg/mL
Application(s):Angiotensin-converting enzyme (ACE) inhibitor; Antihypertensive Agent


 'There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE has two functionally active domains, N and C, which arise from tandem gene duplication. Although the two domains have high sequence similarity, they play distinct physiological roles. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domains, but have much greater affinity for and inhibitory activity against the C-domain. Enalaprilat, the principle active metabolite of enalapril, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI to ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as described in the Pharmacology section above. Enalapril also causes an increase in plasma renin activity likely due to a loss of feedback inhibition mediated by ATII on the release of renin and/or stimulation of reflex mechanisms via baroreceptors. Enalaprilat''s affinity for ACE is approximately 200,000 times greater than that of ATI and 300-1000 times greater than that enalapril. '

[1]D.P. Ip and G.S. Brenner, in K. Florey (Editor), Analytical Profiles of Drug Substances, Vol. 16, Aca- demic Press, London, 1987, pp. 207-243.

X2108Enalaprilat dihydrate

CURRENT AS OF: October 28, 2016

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 APIs and Bioactives > ACE Inhibitors