3543-75-7 Bendamustine HCl AKSci R111
 
 
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  R111    AKSci Reference Standard
Bendamustine HCl, 98% (HPLC)
 
Ribomustin
Treanda
SDX-105
more..
IDENTITY
CAS Number:3543-75-7
MDL Number:MFCD01658758
MF:C16H22Cl3N3O2
MW:394.72
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:152-156°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: 75mg/mL; H2O: 15mg/mL; EtOH: 17mg/mL
Application(s):DNA-damaging agent
Form:HCl salt

REVIEW
 A nitrogen mustard used in the treatment of chronic lymphocytic leukemias and lymphomas. Bendamustine acts as an alkylating agent causing intra-strand and inter-strand cross-links between DNA bases.

REFERENCES
[1]Beeharry N, Rattner JB, Bellacosa A, Smith MR, Yen TJ (2012). Dose dependent effects on cell cycle checkpoints and DNA repair by bendamustine. PLoS One. 7(6):e40342. PMID 22768280.
[2] Chang JE, Kahl BS (2012). Bendamustine for treatment of chronic lymphocytic leukemia. Expert Opin Pharmacother. 13(10):1495-505. PMID 22663160.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H351; H360

Precautionary Statements
P201; P202; P264; P270; P281; P301+P310; P308+P313; P321; P330; P405; P501

RELATED PRODUCTS
R111Bendamustine HCl
X4796Ethyl 4-(5-amino-1-methyl-1H-1,3-benzimidazol-2-yl)butanoate

Current as of May 2, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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