M937 Tauroursodeoxycholic acid dihydrate - AK Scientific
 
 
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  Catalog ID # M937
Tauroursodeoxycholic acid dihydrate
, 98%
 
3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid N-(2-sulfoethyl)amide
TUDCA




IDENTITY
CAS Registry #:[14605-22-2]
MDL Number:MFCD09750398
MF:C26H45NO6S.2H2O
MW:499.71(Anhydrous)
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white powder or crystals
Melting Point:139-153°C
Optical Rotation:+42-+48° (c=1, EtOH)
Shipping:Not Regulated for Shipping

REVIEW

 Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid and is the conjugate form of ursodeoxycholic acid and taurine. Ongoing research finds TUDCA has apoptotic effects, helping with cardiac function, Huntington's disease, Parkinson's Disease, and stroke. Recently, TUDCA has been found to have protective effects in the eye, especially for retinal degenerative disorders. Bax, a molecule that is translocated to the mitochondria to release cytochrome C, initiates the cellular pathway of apoptosis. TUDCA prevents Bax from being transported to the mitochondria. This protects the mitochondria from perturbation and the activation of caspases; therefore TUDCA acts as a chemical chaperone. Recent studies continue to show ocular protective effects via protecting retinal rods against apoptosis, choroidal neovascularization and synaptic connectivity.

REFERENCES
[1]Bonaldi, Antonio; Molinari, Egidio Preparation of taurine-conjugated bile acids Eur. Pat. Appl. (1994), EP 582891 A2 19940216.
[2] Huang, Ling; Zhang, Heping; Qin, Heping; Shen, Huibing; Huang, Wenjun; Liu, Yisong Method for preparation of tauroursodeoxycholic acid hydrate Faming Zhuanli Shenqing (2012), CN 102558268 A 20120711.
[3] Boatright, Jeffrey H.; Nickerson, John M.; Moring, Anisha G.; Pardue, Machelle T. Bile acids in treatment of ocular diseases. Journal of Ocular Biology, Diseases, and Informatics 2009, 2 (3): 149-159.
[4] Boatright, Jeffrey H, Nickerson, John M, Moring, Anisha G, Pardue, Machelle T. Bile acids in treatment of ocular diseas. J Ocul Biol Dis Infor 2009, 2 (3): 149-159.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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RELATED PRODUCTS
M937Tauroursodeoxycholic acid dihydrate
4482ABSodium tauroursodeoxycholate

CURRENT AS OF: June 30, 2015
Availability
1. In Stock: Order today by 4 PM PT and ships today from San Francisco, CA, USA
2. Backordered: Please contact us for availability.
3. If Bulk (kg) is Backordered, sizes less than 1kg may be available.
4. All prices FOB San Francisco, CA, USA
HazMat
HazMat shipping information is based on IATA/DOT regulations. For reference only.
1. Not Required: Not regulated by IATA/DOT. Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

SDS

 M937_SDS.pdf

CATEGORIES

 APIs and Bioactives > Bile Acids

USEFUL LINKS

  PubChem  @PubMed