H764 Prazosin HCl - AK Scientific
 
 
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  Catalog ID # H764
Prazosin HCl
, 98%
 
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine Hydrochloride
Furazosin hydrochloride




IDENTITY
CAS Registry #:[19237-84-4]
MDL Number:MFCD00058177
MF:C19H22ClN5O4
MW:419.86
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White powder
Melting Point:273-282°C
Shipping:Not Regulated for Shipping.

BIOLOGICAL INFO
Solubility:Soluble to 25 mM in DMSO and to 5 mM in ethanol
Application(s):alpha-1-Adrenergic receptor antagonist
Form:HCl salt

REVIEW

 Prazosin acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.

REFERENCES
[1]Bawaskar HS, Bawaskar PH: Utility of scorpion antivenin vs prazosin in the management of severe Mesobuthus tamulus (Indian red scorpion) envenoming at rural setting. J Assoc Physicians India. 2007 Jan;55:14-21.
[2] Cushman WC, Ford CE, Cutler JA, Margolis KL, Davis BR, Grimm RH, Black HR, Hamilton BP, Holland J, Nwachuku C, Papademetriou V, Probstfield J, Wright JT Jr, Alderman MH, Weiss RJ, Piller L, Bettencourt J, Walsh SM: Success and predictors of blood pressure control in diverse North American settings: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). J Clin Hypertens (Greenwich). 2002 Nov-Dec;4(6):393-404.
[3] Hiraoka Y, Taniguchi T, Tanaka T, Okada K, Kanamaru H, Muramatsu I: Pharmacological characterization of unique prazosin-binding sites in human kidney. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jul;368(1):49-56. Epub 2003 Jun 25.

Risk Description(s)
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin
R62:Risk of impaired fertility.

Safety Description(s)
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer).
S36:Wear suitable protective clothing.



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RELATED PRODUCTS
H764Prazosin HCl
H961Prazosin

CURRENT AS OF: May 26, 2015
Availability
1. In Stock: Order today by 4 PM PT and ships today from San Francisco, CA, USA
2. Backordered: Please contact us for availability.
3. If Bulk (kg) is Backordered, sizes less than 1kg may be available.
4. All prices FOB San Francisco, CA, USA
HazMat
HazMat shipping information is based on IATA/DOT regulations. For reference only.
1. Not Required: Not regulated by IATA/DOT. Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

SDS

 H764_SDS.pdf

CATEGORIES

 APIs and Bioactives > Alpha Blockers

USEFUL LINKS

  PubChem