425386-60-3 Semagacestat AKSci X7560
 
 
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  X7560    
Semagacestat, 99% (HPLC)
 
(S)-2-hydroxy-3-methyl-N-((S)-1-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino)-1-oxopropan-2-yl)butanamide
IDENTITY
CAS Number:425386-60-3
MDL Number:MFCD09970409
MF:C19H27N3O4
MW:361.44
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO
Application(s):gamme-Secretase blocker for A-beta42, A-beta40 and A-beta38; also inhibits Notch signaling
Form:Free base
Research Area:Neurological disease

REVIEW
 Semagacestat (LY 450139) is an inhibitor of the gamma-secretase enzyme. This enzyme is pivotal in the generation of beta-amyloid, a neurotoxic endogenous peptide formed by proteolysis of amyloid precursor protein (APP). Research on laboratory rats suggest that the soluble form of this peptide is a causative agent in the development of Alzheimer's.

REFERENCES
[1]Imbimbo, Bruno P.; Peretto, Ilaria. Semagacestat, a γ-secretase inhibitor for the potential treatment of Alzheimer's disease. Current Opinion in Investigational Drugs (BioMed Central). (2009) 10(7): 721-730.
[2] Panza F, Frisardi V, Imbimbo BP, Capurso C, Logroscino G, Sancarlo D, Seripa D, Vendemiale G, Pilotto A, Solfrizzi V. REVIEW: gamma-Secretase inhibitors for the treatment of Alzheimer's disease: The current state. CNS Neurosci Ther. (2010) Oct;16(5): 272-84.
[3] Schellekens, Harriet; McNamara, Orla; Dinan, Timothy G.; McCarthy, Justin V.; McGlacken, Gerard P.; Cryan, John F. Semagacestat, a gamma-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor. Journal of Pharmacy and Pharmacology. (2013) 65(4): 528-538.
[4] Koenig, Thomas Mitchell; Audia, James Edmund; Mitchell, David; McDaniel, Stacey Leigh; Buccilli, Lynne Ann; Engel, Gary Lowell; Aikins, James Abraham Preparation of lactam derivative useful for inhibiting beta-amyloid peptide release and/or its synthesis PCT Int. Appl. (2002), WO 2002040451 A2 20020523

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 2, 2024


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