R787 4-Aza-5alpha-androstan-1-ene-3-one-17beta-carboxylic acid - AK Scientific
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  Catalog ID # R787
4-Aza-5alpha-androstan-1-ene-3-one-17beta-carboxylic acid
, 98% (HPLC)

CAS Registry #:[104239-97-6]
MDL Number:MFCD08063794
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:Off-white to yellow-brown powder
Melting Point:>250°C
Shipping:Not Regulated for Shipping


 4-Aza-5alpha-androstan-1-ene-3-one-17beta-carboxylic acid or Dutasteride (trademark name Avodart, manufactured by GlaxoSmithKline) is a dual (type 1 and 2) 5-alpha reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). It is used for benign prostatic hyperplasia and its chemopreventation, however increases the risk of erectile dysfunction and decrease sexual desire.

[1]Zhao, Shuang; Bioorganic & Medicinal Chemistry Letters 2011, V21(11), P3439-3442
[2] Satyanarayana, Komati; Organic Process Research & Development 2007, V11(5), P842-845
[3] Zhang, Kui-Ping; Journal of Chinese Pharmaceutical Sciences 2007, V16(3), P233-235
[4] Rasmusson, Gary H.; Reynolds, Glenn F.; Steinberg, Nathan G.; Walton, Edward; Patel, Gool F.; Liang, Tehming; Cascieri, Margaret A.; Cheung, Anne H.; Brooks, Jerry R.; Berman, Charles; Azasteroids: structure-activity relationships for inhibition of 5alpha-reductase and of androgen receptor binding. Journal of Medicinal Chemistry (1986), 29(11), 2298-315.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.

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CURRENT AS OF: August 1, 2015
1. In Stock: Order today by 4 PM PT and ships today from San Francisco, CA, USA
2. Backordered: Please contact us for availability.
3. If Bulk (kg) is Backordered, sizes less than 1kg may be available.
4. All prices FOB San Francisco, CA, USA
HazMat shipping information is based on IATA/DOT regulations. For reference only.
1. Not Required: Not regulated by IATA/DOT. Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.




 APIs and Bioactives > Antiandrogens, Steroid Hormones


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