REVIEW 4-Aza-5alpha-androstan-1-ene-3-one-17beta-carboxylic acid or Dutasteride (trademark name Avodart, manufactured by GlaxoSmithKline) is a dual (type 1 and 2) 5-alpha reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). It is used for benign prostatic hyperplasia and its chemopreventation, however increases the risk of erectile dysfunction and decrease sexual desire.
Satyanarayana, Komati; Organic Process Research & Development 2007, V11(5), P842-845
Zhang, Kui-Ping; Journal of Chinese Pharmaceutical Sciences 2007, V16(3), P233-235
Rasmusson, Gary H.; Reynolds, Glenn F.; Steinberg, Nathan G.; Walton, Edward; Patel, Gool F.; Liang, Tehming; Cascieri, Margaret A.; Cheung, Anne H.; Brooks, Jerry R.; Berman, Charles; Azasteroids: structure-activity relationships for inhibition of 5alpha-reductase and of androgen receptor binding. Journal of Medicinal Chemistry (1986), 29(11), 2298-315.
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