100361-18-0 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic acid AKSci R369
 
 
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  R369    AKSci Bulk Reagent
1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic acid, 98%
 



IDENTITY
CAS Number:100361-18-0
MDL Number:MFCD08458865
MF:C12H8ClFN2O3
MW:282.65
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:222-226°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 1-Cyclopropyl-6-fluoro-7-chloride-4-oxo-1,4-dihydro-1,8-napthyridine-3-carboxylic acid is a key intermediate in the synthesis of 7-amine based fluoroquinoline antibacterials agents. Reaction at the 7- chloro with amines, in particular secondary amines, gives rise to a range of fluoroquinolones with antibacterial activity.

REFERENCES
[1]Mich, Thomas F.; Sanchez, Joseph P.; Domagala, John M.; Trehen, Ashok K. 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 1-cyclopropyl-1, 4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids and their derivatives Eur. Pat. Appl. (1985), EP 153828 A2 19850904.
[2] Hayakawa, Isao 1,8-Naphthyridine derivatives Jpn. Kokai Tokkyo Koho (1985), JP 60172981 A 19850906.
[3] Mich, Thomas F.; Sanchez, Joseph P.; Domagala, John M. Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids; substituted-5-amino-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and pharmaceutical compositions compris Eur. Pat. Appl. (1986), EP 172651 A1 19860226.
[4] Sanchez, Joseph P.; Domagala, John M.; Hagen, Susan E.; Heifetz, Carl L.; Hutt, Marland P.; Nichols, Jeffry B.; Trehan, Ashok K. Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids Journal of Medicinal Chemistry (1988), 31(5), 983-91.
[5] Nishimura, Yoshiro; Hirose, Tohru; Okada, Hidetsugu; Shibamori, Kohichiro; Nakano, Junji; Matsumoto, Junichi Pyridonecarboxylic acid antibacterial agents. XV. Synthesis of 7-thio-substituted 4-oxoquinoline-3-carboxylic acids with antibacterial activity Chemical & Pharmaceutical Bulletin (1990), 38(8), 2190-6.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 29, 2024


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⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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CATEGORIES
 APIs and Bioactives > Antibacterials, Quinolones


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