REVIEW Yohimbine is a pre-synaptic alpha 2-adrenergic blocking agent. The exact mechanism for its use in impotence has not been fully elucidated. However, yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei. Yohimbine-mediated norepinephrine release at the level of the corporeal tissues may also be involved. In addition, beneficial effects may involve other neurotransmitters such as dopamine and serotonin and cholinergic receptors.
Rosengren, A. H.; Jokubka, R.; Tojjar, D.; Granhall, C.; Hansson, O.; Li, D.-Q.; Nagaraj, V.; Reinbothe, T. M. et al. (2009). Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes. Science 327 (5962): 217-20. doi:10.1126/science.1176827. PMID 19965390.
Saenz De Tejada, I; Kim, NN; Goldstein, I; Traish, AM (2000). Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum. International Journal of Impotence Research 12 Suppl 1: S20-25. doi:10.1038/sj.ijir.3900500. PMID 10845761.
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