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BIOLOGICAL INFO
Solubility:
DMSO: 67mg/mL; H2O: <1mg/mL; EtOH: 5mg/mL
Application(s):
Cardiotonic Agent; Vasodilator Agent; Selective Phosphodiesterase III (PDE3) Inhibitor
Form:
Free Base
REVIEW Pimobendan is a positive inotrope. It sensitizes and increases the binding efficiency of cardiac myofibril to the calcium ions that are already present without increasing the consumption of oxygen and energy. The drug also causes peripheral vasodilation by inhibiting the function of phosphodiesterase III. This results in decreased pressure, translating into smaller cardiac preload and afterload.
REFERENCES
[1]
Gordon SG, Saunders AB, Roland RM, Winter RL, Drourr L, Achen SE, Hariu CD, Fries RC, Boggess MM, Miller MW (2012). Effect of oral administration of pimobendan in cats with heart failure. J Am Vet Med Assoc. 241(1):89-94. PMID 22720992.
[2]
Macgregor JM, Rush JE, Laste NJ, Malakoff RL, Cunningham SM, Aronow N, Hall DJ, Williams J, Price LL (2011). Use of pimobendan in 170 cats (2006-2010). J Vet Cardiol. 13(4):251-60. PMID 22030289.
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