22255-22-7 3,4',5-Trimethoxystilbene AKSci J53792
 
 
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  J53792    AKSci Bulk Reagent
3,4',5-Trimethoxystilbene, 95%
 
E-Resveratrol Trimethyl Ether, 1,3-dimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene
Tri-O-methylresveratrol
Trimethoxy-trans-stilbene
IDENTITY
CAS Number:22255-22-7
MDL Number:MFCD02093500
MF:C17H18O3
MW:270.32
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:65-67°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN3077
Hazard Class:9; Miscellaneous
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: =34 mg/mL

REVIEW
 3,4',5-Trimethoxystilbene, an antiangiogenic agent and permethylated derivative of Resveratrol, has been shown to inhibit endothelial cell proliferation, and cause microtubule disassembly and tubulin depolymerization. It has been reported that this compound induces apoptosis via modulation of mitochondrial functions regulated by reactive oxygen species. Further studies note that 3,4',5-Trimethoxystilbene causes reactive oxygen species generation in the early stages of the induced apoptosis, preceding cytochrome-c release, caspase activation, and DNA fragmentation.

REFERENCES
[1]Matsuda, H., et al. 2004. Bioorg. Med. Chem. 12: 4871-4876. PMID: 15336266
[2] de Medina, P., et al. 2005. J. Med. Chem. 48: 287-291. PMID: 15634023
[3] Belleri, M., et al. 2005. Mol. Pharmacol. 67: 1451-1459. PMID: 15703378
[4] Pan, M.H., et al. 2008. Mol. Carcinog. 47: 184-196. PMID: 18085528

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H315; H318; H335; H410

Precautionary Statements
P261; P264; P271; P273; P280; P302+P352; P304+P340; P305+P351+P338; P310; P321; P332+P313; P362; P391; P403+P233; P405; P501

Current as of May 2, 2024


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⚠️
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