REVIEW Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited.
REFERENCES
[1]
Meggio, F., et al.: Biochemistry, 43, 12931 (2004)
[2]
Traxler, P., et al.: J. Med. Chem., 42, 1018 (1999)
[3]
Battistutta, R., et al.: J. Biol. Chem., 275, 29618 (2000)
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