39562-70-4 Nitrendipine AKSci J10689
 
 
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  J10689    
Nitrendipine, >98% (HPLC)
 
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester
IDENTITY
CAS Number:39562-70-4
MDL Number:MFCD00082255
MF:C18H20N2O6
MW:360.36
EINECS:254-513-1
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:158°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:MeOH: 15mg/mL; DMSO: 17.5 mg/mL
Application(s):Dihydropyridine calcium channel blocker

REVIEW
 Nitrendipine is a racemic dihydropyridine calcium channel blocker for the treatment of primary hypertension.

REFERENCES
[1]Meyer, Horst; Bossert, Friedrich; Vater, Wulf; Stoepel, Kurt Dialkyl 4-aryl-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylates Ger. Offen. (1972), DE 2117571 A 19721019.
[2] Meyer, H.; Bossert, F.; Wehinger, E.; Stoepel, K.; Vater, W. Synthesis and comparative pharmacological studies of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylates with non-identical ester functions Arzneimittel-Forschung (1981), 31(3), 407-9.
[3] Meyer, Horst; Bossert, Friedrich; Wehinger, Egbert; Scherling, Dietrich Chemistry of nitrendipine and its metabolites Edited by Scriabine, Alexander; Vanov, Svetislav; Deck, Klaus Nitrendipine (1984), 1-9.
[4] Goa KL, Sorkin EM. Nitrendipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension. Drugs. 1987 Feb;33(2):123-55.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H312+H332

Precautionary Statements
P261; P271; P280; P302+P352; P304+P340; P312; P322; P363; P501

Current as of May 2, 2024


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CATEGORIES
 APIs and Bioactives > Calcium Channel Blockers


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