REVIEW 4-Phenylbutyrate is a salt of an aromatic fatty acid. The drug has been used to treat urea cycle disorders. Sodium phenylbutyrate metabolites allows the kidneys to excrete excess nitrogen in place of urea. Phenylbutyrate is a prodrug.
REFERENCES
[1]
Welsch L, Welsch T, Dovzhanskiy DI, Felix K, Giese NA, Krysko DV, Werner J (2012). Impact of the histone deacetylase inhibitor 4-phenylbutyrate on the clearance of apoptotic pancreatic carcinoma cells by human macrophages. Int J Oncol. 40(2):427-35. PMID 22020984.
[2]
Hayashi H, Mizuno T, Horikawa R, Nagasaka H, Yabuki T, Takikawa H, Sugiyama Y (2012). 4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration. J Hepatol. 56(5):1136-44. PMID 22245901.
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