86299-47-0 Ceftazidime Impurity 1 AKSci J10372
 
 
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  J10372    AKSci Reference Standard
Ceftazidime Impurity 1, >98% (HPLC)
 
(Z)-2-(2-Aminothiazol-4-yl)-2-[(1-tert-butoxycarbonyl-1-methylethoxy)imino]acetic acid
IDENTITY
CAS Number:86299-47-0
MDL Number:MFCD00071569
MF:C13H19N3O5S
MW:329.37
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:180-187°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 An advanced intermediate to side chains used in beta-lactam antibiotics e.g. aztreonam and ceftazidime.

REFERENCES
[1]Hubschwerlen, Christian Nicolas; Schmid, Gerard Optically uniform beta-lactams and their use in the preparation of antimicrobial beta-lactams, and starting compounds for use in their preparation Eur. Pat. Appl. (1983), EP 73061 A2 19830302.
[2] Takanohashi, Kunio; Yoshida, Tsuneaki; Fujii, Shoichiro Aminothiazoleacetic acid derivatives PCT Int. Appl. (1984), WO 8404305 A1 19841108.
[3] Nishimura, Tatsuo; Yoshimura, Yoshinobu; Yamaoka, Masayoshi; Kawai, Tatsuhiko; Miyake, Akio Studies on condensed-heterocyclic azolium cephalosporins. I. Synthesis and antibacterial activity of 7beta-[2-(2-aminothiazol-4-yl)-2(Z)-alkoxyiminoacetamido]-3-(imidazo[1,2-a]pyridinium-1-yl)methyl-3-cephem-4-carboxylates Journal of Antibiotics (1991), 44(12), 1371-93.
[4] Handa, Vijay Kumar; Gupta, Surinder Mohan; Maheshwari, Nittin; Rohatgi, Amit Process for the preparation of crystalline (Z)-2-(2-tert-butoxycarbonylprop-2-oxyimino)-2-(2-triphenylmethylaminothiazol-4-yl)acetic acid in association with N,N-dimethylformamide U.S. (2001), US 6214997 B1 20010410.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 29, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Cephalosporins
 Heterocyclic Building Blocks > Thiazoles, Amines, Ethers, Esters
 Heterocyclic Building Blocks > Thiazoles, Amines, Ethers, Esters


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