1744-22-5 Riluzole AKSci J10184
 
 
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  J10184    AKSci Reference Standard
Riluzole, >98% (HPLC), powder
 
2-Amino-6-(trifluoromethoxy)benzothiazole
6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
Rilutek
IDENTITY
CAS Number:1744-22-5
MDL Number:MFCD00210213
MF:C8H5F3N2OS
MW:234.2
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:113-118°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:II
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: 47mg/mL; H2O: <1mg/mL; EtOH: 47mg/mL
Application(s):Anticonvulsant; Excitatory Amino Acid Antagonist; Neuroprotective Agent
Form:Free Base
Research Area:FDA approved in December of 1995 for amyotrophic lateral sclerosis.

REVIEW
 Riluzole preferentially blocks TTX-sensitive sodium channels, which are associated with damaged neurons. This reduces influx of calcium ions and indirectly prevents stimulation of glutamate receptors.

REFERENCES
[1]Song JH, Huang CS, Nagata K, Yeh JZ, Narahashi T: Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J Pharmacol Exp Ther. 1997 Aug;282(2):707-14.
[2] Coric V, Taskiran S, Pittenger C, Wasylink S, Mathalon DH, Valentine G, Saksa J, Wu YT, Gueorguieva R, Sanacora G, Malison RT, Krystal JH: Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial. Biol Psychiatry. 2005 Sep 1;58(5):424-8.
[3] van Kan HJ, Groeneveld GJ, Kalmijn S, Spieksma M, van den Berg LH, Guchelaar HJ: Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis. Br J Clin Pharmacol. 2005 Mar;59(3):310-3.
[4] Zarate CA Jr, Payne JL, Quiroz J, Sporn J, Denicoff KK, Luckenbaugh D, Charney DS, Manji HK: An open-label trial of riluzole in patients with treatment-resistant major depression. Am J Psychiatry. 2004 Jan;161(1):171-4.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H300

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501

Current as of May 2, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Anticonvulsants


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