REVIEW Prulifloxacin is a tricyclic fluoroquinolone antibacterial prodrug. Upon absorption, prulifloxacin is metabolised by esterases to ulifloxacin, the active compound which possesses broad activity against enteric and nonenteric gram-negative bacilli. Prulifloxacin has shown multimodal mechanism of action and inhibits both DNA gyrase and topoisomerase IV enzyme, leading to increased antibacterial spectrum via DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. It has been approved for the treatment of uncomplicated and complicated urinary tract infections, community-acquired respiratory tract infections in Italy, and gastroenteritis, including infectious diarrheas, in Japan. Prulifloxacin has not been approved for use in the United States.
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