Central Nervous System Stimulant; Respiratory System Agent
REVIEW Doxapram HCl is an analeptic agent (a stimulant of the central nervous system), a central respiratory stimulant with a brief duration of action. It produces respiratory stimulation mediated through the peripheral carotid chemoreceptors. Therefore, it is used in intensive care settings to stimulate the respiratory rate in patients with respiratory failure.
Boutroy, Marie-Jeanne. Pharmacology and use of methylxanthines and doxapram for the treatment of neonatal apnea. Edited by Jacqz-Aigrain; Choonara, Imti. Paediatric Clinical Pharmacology. (2006) 417-423.
Yost CS. A new look at the respiratory stimulant doxapram. CNS Drug Rev. (2006) Fall-Winter;12(3-4): 236-49.
Bhatia J. Current options in the management of apnea of prematurity. Clinical pediatrics. (2000) 39(6): 327-36.
Lunsford, Carl D.; Cale, Albert D., Jr.4-(omega-Substituted alkyl)-3,3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3,3-disubstituted-1-substituted-2-pyrrolidinethiones (1965), US 3192221 19650629
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