[4342-03-4] Dacarbazine AKSci H539
 
 
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  Catalog ID # H539
Dacarbazine
, 97% (HPLC)
 
DTIC
5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide
Dacatic
more..




IDENTITY
CAS Number:[4342-03-4]
MDL Number:MFCD00057167
MF:C6H10N6O
MW:182.1832
EINECS:224-396-1
SPECIFICATIONS & PROPERTIES
Purity:97% (HPLC)
Available Spectra:FT-IR, LCMS, HPLC
Physical Form:White to off-white to light yellow powder
Melting Point:207-212°C
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Solubility:DMSO: 3mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):DNA Synthesis
Form:Free Base

REVIEW

 An antineoplastic chemotherapy drug used in the treatment of various cancers. Dacarbazine is a member of the class of alkylating agents that destroy cancer cells by adding an alkyl group (CnH2n+1) to its DNA.

REFERENCES
[1]Margolin K (2012). BRAF inhibition and beyond in advanced melanoma. Lancet. 380(9839):320-2. PMID 22735383.
[2] Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, Rutkowski P, Blank CU, Miller WH Jr, Kaempgen E, Martín-Algarra S, Karaszewska B, Mauch C, Chiarion-Sileni V, Martin AM, Swann S, Haney P, Mirakhur B, Guckert ME, Goodman V, Chapman PB (2012). Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012 Jul 28;380(9839):358-65. PMID 22735384.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H302+H312+H332; H315; H319; H335; H340; H350

Precautionary Statements
P201; P202; P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P308+P313; P322; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of December 4, 2016


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CATEGORIES

 APIs and Bioactives > Chemotherapeutics

USEFUL LINKS

  PubChem