H539 Dacarbazine - AK Scientific
 
 
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  Catalog ID # H539
Dacarbazine
, 97% (HPLC)
 
DTIC
5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide
Dacatic
Deticene




IDENTITY
CAS Registry #:[4342-03-4]
MDL Number:MFCD00057167
MF:C6H10N6O
MW:182.1832
EINECS:224-396-1
SPECIFICATIONS & PROPERTIES
Purity:97% (HPLC)
Available Spectra:FT-IR, LCMS, HPLC
Physical Form:White to off-white to light yellow powder
Melting Point:207-212°C
Long-Term Storage:Store long-term at -20°C
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Solubility:DMSO: 3mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):DNA Synthesis
Form:Free Base

REVIEW

 An antineoplastic chemotherapy drug used in the treatment of various cancers. Dacarbazine is a member of the class of alkylating agents that destroy cancer cells by adding an alkyl group (CnH2n+1) to its DNA.

REFERENCES
[1]Margolin K (2012). BRAF inhibition and beyond in advanced melanoma. Lancet. 380(9839):320-2. PMID 22735383.
[2] Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, Rutkowski P, Blank CU, Miller WH Jr, Kaempgen E, Mart?n-Algarra S, Karaszewska B, Mauch C, Chiarion-Sileni V, Martin AM, Swann S, Haney P, Mirakhur B, Guckert ME, Goodman V, Chapman PB (2012). Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012 Jul 28;380(9839):358-65. PMID 22735384.

Risk Description(s)
R45:May cause cancer.
R46:May cause heritable genetic damage.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S53:Avoid exposure - obtain special instructions before use.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



Pricing

CURRENT AS OF: May 29, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 H539_SDS.pdf

CATEGORIES

 APIs and Bioactives > Chemotherapeutics

USEFUL LINKS

  PubChem