H539 Dacarbazine - AK Scientific
 
 
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  Catalog ID # H539
Dacarbazine
, 98% (HPLC)
 
DTIC
5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide
Dacatic
Deticene




IDENTITY
CAS Registry #:[4342-03-4]
MDL Number:MFCD00057167
MF:C6H10N6O
MW:182.1832
EINECS:224-396-1
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to off-white to light yellow powder
Melting Point:207-212°C
Long-Term Storage:Store long-term at -20°C
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Solubility:DMSO: 3mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):DNA Synthesis
Form:Free Base

REVIEW

 An antineoplastic chemotherapy drug used in the treatment of various cancers. Dacarbazine is a member of the class of alkylating agents that destroy cancer cells by adding an alkyl group (CnH2n+1) to its DNA.

REFERENCES
[1]Margolin K (2012). BRAF inhibition and beyond in advanced melanoma. Lancet. 380(9839):320-2. PMID 22735383.
[2] Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, Rutkowski P, Blank CU, Miller WH Jr, Kaempgen E, Mart?n-Algarra S, Karaszewska B, Mauch C, Chiarion-Sileni V, Martin AM, Swann S, Haney P, Mirakhur B, Guckert ME, Goodman V, Chapman PB (2012). Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012 Jul 28;380(9839):358-65. PMID 22735384.

Risk Description(s)
R45:May cause cancer.
R46:May cause heritable genetic damage.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S53:Avoid exposure - obtain special instructions before use.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



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CURRENT AS OF: May 28, 2015
Availability
1. In Stock: Order today by 4 PM PT and ships today from San Francisco, CA, USA
2. Backordered: Please contact us for availability.
3. If Bulk (kg) is Backordered, sizes less than 1kg may be available.
4. All prices FOB San Francisco, CA, USA
HazMat
HazMat shipping information is based on IATA/DOT regulations. For reference only.
1. Not Required: Not regulated by IATA/DOT. Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

SDS

 H539_SDS.pdf

CATEGORIES

 APIs and Bioactives > Chemotherapeutics

USEFUL LINKS

  PubChem