REVIEW In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.
Ratomponirina C, Gobaille S, Hodé Y, Kemmel V, Maitre M (Apr 1998). Sulpiride, but not haloperidol, up-regulates gamma-hydroxybutyrate receptors in vivo and in cultured cells. Eur J Pharmacol. 346 (2-3): 331-7. doi:10.1016/S0014-2999(98)00068-5. PMID 9652377.
Maitre M, Ratomponirina C, Gobaille S, Hodé Y, Hechler V (Apr 1994). Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics. Eur J Pharmacol. 256 (2): 211-4. doi:10.1016/0014-2999(94)90248-8. PMID 7914168.
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