H498 (+/-)-Sulpiride - AK Scientific
 
 
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  Catalog ID # H498
(+/-)-Sulpiride
, 98% (HPLC)
 
)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide




IDENTITY
CAS Registry #:[15676-16-1]
MDL Number:MFCD00055061
MF:C15H23N3O4S
MW:341.43
EINECS:239-753-7
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC, Polarimetry
Physical Form:White to yellow crystalline powder
Melting Point:178-187°C
Optical Rotation:-3.0° - +3.0° (c=0.5, DMF)
Long-Term Storage:Store long-term at 2-8°C
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Application(s):A D2DR inhibitor

REVIEW

 In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.

REFERENCES
[1]Ratomponirina C, Gobaille S, Hod? Y, Kemmel V, Maitre M (Apr 1998). Sulpiride, but not haloperidol, up-regulates gamma-hydroxybutyrate receptors in vivo and in cultured cells. Eur J Pharmacol. 346 (2-3): 331-7. doi:10.1016/S0014-2999(98)00068-5. PMID 9652377.
[2] Maitre M, Ratomponirina C, Gobaille S, Hod? Y, Hechler V (Apr 1994). Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics. Eur J Pharmacol. 256 (2): 211-4. doi:10.1016/0014-2999(94)90248-8. PMID 7914168.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.



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CURRENT AS OF: July 3, 2015
Availability
1. In Stock: Order today by 4 PM PT and ships today from San Francisco, CA, USA
2. Backordered: Please contact us for availability.
3. If Bulk (kg) is Backordered, sizes less than 1kg may be available.
4. All prices FOB San Francisco, CA, USA
HazMat
HazMat shipping information is based on IATA/DOT regulations. For reference only.
1. Not Required: Not regulated by IATA/DOT. Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

SDS

 H498_SDS.pdf

CATEGORIES

 APIs and Bioactives > Antipsychotics

USEFUL LINKS

  PubChem