[15676-16-1] (+/-)-Sulpiride AKSci H498
 
 
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  Catalog ID # H498
(+/-)-Sulpiride
, 98% (HPLC)
 
(+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
(+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide




IDENTITY
CAS Number:[15676-16-1]
MDL Number:MFCD00055061
MF:C15H23N3O4S
MW:341.43
EINECS:239-753-7
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to yellow crystalline powder
Melting Point:178-187°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:0.1M HCl; EtOH
Application(s):A D2DR inhibitor

REVIEW

 In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.

REFERENCES
[1]Ratomponirina C, Gobaille S, Hodé Y, Kemmel V, Maitre M (Apr 1998). Sulpiride, but not haloperidol, up-regulates gamma-hydroxybutyrate receptors in vivo and in cultured cells. Eur J Pharmacol. 346 (2-3): 331-7. doi:10.1016/S0014-2999(98)00068-5. PMID 9652377.
[2] Maitre M, Ratomponirina C, Gobaille S, Hodé Y, Hechler V (Apr 1994). Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics. Eur J Pharmacol. 256 (2): 211-4. doi:10.1016/0014-2999(94)90248-8. PMID 7914168.



Current as of December 4, 2016


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CATEGORIES

 APIs and Bioactives > Antipsychotics

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