H498 (+/-)-Sulpiride - AK Scientific
 
 
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  Catalog ID # H498
(+/-)-Sulpiride
, 98% (HPLC)
 
(+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
(+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide




IDENTITY
CAS Registry #:[15676-16-1]
MDL Number:MFCD00055061
MF:C15H23N3O4S
MW:341.43
EINECS:239-753-7
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to yellow crystalline powder
Melting Point:178-187°C
Long-Term Storage:Store long-term at 2-8°C
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Solubility:0.1M HCl; EtOH
Application(s):A D2DR inhibitor

REVIEW

 In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.

REFERENCES
[1]Ratomponirina C, Gobaille S, Hodé Y, Kemmel V, Maitre M (Apr 1998). Sulpiride, but not haloperidol, up-regulates gamma-hydroxybutyrate receptors in vivo and in cultured cells. Eur J Pharmacol. 346 (2-3): 331-7. doi:10.1016/S0014-2999(98)00068-5. PMID 9652377.
[2] Maitre M, Ratomponirina C, Gobaille S, Hodé Y, Hechler V (Apr 1994). Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics. Eur J Pharmacol. 256 (2): 211-4. doi:10.1016/0014-2999(94)90248-8. PMID 7914168.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.



Pricing

CURRENT AS OF: September 26, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 H498_SDS.pdf

CATEGORIES

 APIs and Bioactives > Antipsychotics

USEFUL LINKS

  PubChem