G606 Rotundine - AK Scientific
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  Catalog ID # G606
formerly cat #71606
, 98%

CAS Registry #:[2934-97-6]
MDL Number:MFCD00214191
Physical Form:White powder
Melting Point:147°C
Optical Rotation:-291° (c=0.8, in 95% alcohol)
Long-Term Storage:Store at room temperature
Shipping:Not Regulated for Shipping


 Rotundine or Tetrahydropalmatine is a racemic naturally occurring plant alkaloid found predominatly in the Corydalis genus, but also in other plants such as Stephania rotunda. These plants have traditional uses in Chinese herbal medicine. Rotundine has been demonstrated to possess analgesic effects and may be beneficial in the treatment of heart disease and liver damage. It is a potent muscle relaxant, with a very intriguing pharmacological profile: antagonism of dopamine D1 and D2 receptors and actions at dopamine D3, alpha adrenergic and serotonin receptors It has also shown potential in the treatment of drug addiction to both cocaine and opiates, and preliminary human studies have shown promising results. Dopamine, an important neurotransmitter in the central nervous system, occurs in several important signaling systems that regulate muscular activity and attention, as well as feelings of joy, enthusiasm and creativity. Therefore, Rotundine causes no feelings of euphoria, and has been seen as an alternative to addictive drugs for people suffering from anxiety and pain, and as a possibility for relief for people not helped by existing drugs.

[1]Wu L, Ling H, Li L, Jiang L, He M.Beneficial effects of the extract from Corydalis yanhusuo in rats with heart failure following myocardial infarction. J Pharm Pharmacol. 2007 May;59(5):695-701.
[2] Chu H, Jin G, Friedman E, Zhen X. Recent development in studies of tetrahydroprotoberberines: mechanism in antinociception and drug addiction. Cell Mol Neurobiol. 2008 Jun;28(4):491-9. Epub 2007 Aug 21.
[3] Shorter D, Kosten TR. Novel pharmacotherapeutic treatments for cocaine addiction. BMC Med. 2011 Nov 3;9:119. doi: 10.1186/1741-7015-9-119.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.

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CURRENT AS OF: February 12, 2016

1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.
1. Not Required: Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.




 APIs and Bioactives > Alkaloids


  PubChem  @PubMed