REVIEW Clobetasol propionate is a corticosteroid used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy or oak. It is a derivative of prednisolone with high glucocorticoid activity and low mineralocorticoid activity and belongs to US Class I (Europe class IV), making it one of the most potent available. It is also used to treat several auto-immune diseases including alopecia areata, vitiligo and lichen planus. Clobetasol propionate exerts antiinflammatory, immunosuppressive and antimitotic effects influencing the growth, differentiation and function of various cells and inhibiting cytokine production.
REFERENCES
[1]
Elks, Joseph; Phillipps, Gordon Hanley Halopregnenones Ger. Offen. (1969), DE 1902340 A1 19690911.
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