REVIEW H1152 is a potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK, with an IC50 of 12 nM for ROCKII. H1152 poorly inhibits PKA, PKC, and myosin light chain kinase.
Rho kinase (ROCK), activated by GTP-linked Rho, phosphorylates targets that are involved in cytoskeletal remodelling, smooth muscle contraction, and neuronal development.
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