871543-07-6 H-1152 dihydrochloride AKSci SYN1221
 
 
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  SYN1221    
H-1152 dihydrochloride
, >95%
 
H-1152




IDENTITY
CAS Number:871543-07-6
MDL Number:MFCD06411451
MF:C16H21N3O2S.2HCl
MW:392.34
SPECIFICATIONS & PROPERTIES
Purity:>95%
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:Soluble in DMSO

REVIEW

 H1152 is a potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK, with an IC50 of 12 nM for ROCKII. H1152 poorly inhibits PKA, PKC, and myosin light chain kinase. Rho kinase (ROCK), activated by GTP-linked Rho, phosphorylates targets that are involved in cytoskeletal remodelling, smooth muscle contraction, and neuronal development.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 3, 2020


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