1402345-92-9 GSK-F1 AKSci SYN1220
 
 
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  SYN1220    
GSK-F1
, >95%
 
GSKF1




IDENTITY
CAS Number:1402345-92-9
MF:C27H18F5N5O4S
MW:603.52
SPECIFICATIONS & PROPERTIES
Purity:>95%
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:Soluble in DMSO

REVIEW

 GSK-F1 is a potent inhibitor of PI4KA. It has markedly better pharmacokinetic properties in vivo with respects to GSK-A1 (SYN-1219). GSK-F1 does not cross the blood-brain barrier. Phosphatidylinositol 4-kinase type III-alpha (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory host factor in HCV replication. Down-regulation of PI4KA appears to be reasonably tolerated by cultured cell models and results.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of April 25, 2019


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