1404095-34-6 CCT244747 AKSci SYN1216
 
 
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  SYN1216    
CCT244747
, >95%
 



IDENTITY
CAS Number:1404095-34-6
MDL Number:MFCD25977017
MF:C20H24N8O2
MW:408.46
SPECIFICATIONS & PROPERTIES
Purity:>95%
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:Soluble in DMSO

REVIEW

 CCT244747 is a novel, potent, highly selective, orally active, ATP competitive CHK1 inhibitor. CCT244747 can inhibit cellular CHK1 activity with an IC50 of 29-170nM. In multiple tumour cell models, this has the effect of significantly enhancing the cytotoxicity of several anticancer drugs (such as gemcitabine and irinotecan) and abrogating drug-induced S and G2 arrest.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 12, 2020


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