579515-63-2 GW806742X AKSci SYN1215
 
 
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  SYN1215    
GW806742X
, >95%
 
AC1NS7PT
AGN-PC-0LQ49Y




IDENTITY
CAS Number:579515-63-2
MDL Number:MFCD29036385
MF:C25H22F3N7O4S
MW:573.55
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>95%
Physical Form:White powder
Long-Term Storage:Store at room temperature
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):VEGFR2 - YES - MLKL

REVIEW

 GW806742X is a nanomolar inhibitor of the protein kinase, VEGFR2 (2nm) and also binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis. With regards to its role in necroptosis, GW806742X is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited TSQ-induced death of mouse dermal fibroblasts by delaying MLKL translocation to the membrane. GW806742X therefore appears to be a valuable reagent to inhibit necroptosis. It also provides an important proof-of-principle that targeting catalytically-dead pseudoenzymes represents a feasible, emerging therapeutic avenue.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of March 5, 2021


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