1025065-69-3 SGI-1776 AKSci SYN1193
 
 
Loading Please Wait...
  SYN1193    
SGI-1776
, >95%
 
SGI1776




IDENTITY
CAS Number:1025065-69-3
MDL Number:MFCD16659064
MF:C20H22F3N5O
MW:405.42
SPECIFICATIONS & PROPERTIES
Purity:>95%
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO 81mg/mL, Ethanol < 81mg/mL
Application(s):Pim1 - Pim2 - Pim3

REVIEW

 SGI-1776 is a novel ATP competitive inhibitor of Pim1 with an IC50 of 7 nM, 50- and 10-fold selectivity versus Pim2 and Pim3. SGI-1776 also however inhibits FLT3 kinase which can complicate some experimental results if not carefully controlled. In 2010 SGI-1776 clinical trials were postponed because of patient toxicity to SGI-1776.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of November 13, 2019


Download SDS

For research use only. Not for diagnostic or therapeutic use.
Not for human use.



PubChem