848344-36-5 Bentamapimod AKSci SYN1147
 
 
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  SYN1147    
Bentamapimod, 98%
 
AS-602801
IDENTITY
CAS Number:848344-36-5
MDL Number:MFCD08272350
MF:C25H23N5O2S
MW:457.55
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:10.8 mg/mL in DMSO
Application(s):PDGFR

REVIEW
 Bentamapimod (AS602801) is a novel and orally active c-Jun-N-Terminal Kinase Inhibitor highly specific for JNK kinases. The inhibitorBentamapimod (AS602801) is a potent anti-inflammatory agent which has been shown to reduce the disease burden in several pre-clinical models for endometriosis, and has the potential to be effective in addressing the causes of post-operative abdominal adhesions. Pre-clinical data have demonstrated Bentamapimod to be an effective anti-inflammatory with anti-fibrotic properties. Bentamapimod (AS602801) showed good bioavailability in rats (F=50%) andBentamapimod (AS602801) does cross the blood brain barrier, with 98% brain penetration and so far the drug has been well tolerated. Bentamapimod (AS602801)is a potent and selective JNK inhibitor with therapeutic potential in MS and fibrosis as well.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 23, 2024


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