433-97-6 2-(Trifluoromethyl)benzoic acid AKSci J93330
 
 
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  J93330    AKSci Bulk Reagent
2-(Trifluoromethyl)benzoic acid
, 95%
 



IDENTITY
CAS Number:433-97-6
MDL Number:MFCD00002476
MF:C8H5F3O2
MW:190.12
EINECS:207-093-9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:106-110°C
Boiling Point:247°C(753mmHg)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 2-(Trifluoromethyl)benzoic acid was used in the synthesis of 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety. It was also used to investigate the binding of 2-pyridinone and amino acid derivative as ligands with chaperones PapD and FimC by surface plasmon resonance and 1HNMR spectroscopy.

REFERENCES
[1]B Chandrakantha, Prakash Shetty, Vijesh Nambiyar, Nishitha Isloor, Arun M Isloor, Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety, European journal of medicinal chemistry 2009-12-17.
[2] Tobias Tengel, Tomas Fex, Hans Emtenas, Fredrik Almqvist, Ingmar Sethson, Jan Kihlberg, Use of 19F NMR spectroscopy to screen chemical libraries for ligands that bind to proteins. Organic & biomolecular chemistry 2004-2-27.
[3] F Y Ghauri, C A Blackledge, I D Wilson, J K Nicholson, Studies on the metabolism of fluorinated xenobiotics in the rat using 19F-NMR and 1H-NMR spectroscopy. Journal of pharmaceutical and biomedical analysis 1990-1-1.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of April 24, 2024


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⚠️
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CATEGORIES

 Aryl and Aliphatic Building Blocks > Carboxylic Acids, Trifluoromethyl Compounds


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