13647-35-3 Trilostane AKSci J11209
 
 
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  J11209    AKSci Reference Standard
Trilostane
, 99% (HPLC)
 
(4alpha,5alpha,17beta-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
Vetoryl

Structure N/A

IDENTITY
CAS Number:13647-35-3
MDL Number:MFCD00199295
MF:C20H27NO3
MW:329.43
EINECS:237-133-0
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Physical Form:White to off-white powder
Melting Point:257-270°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:DMSO: >=17mg/mL;H 2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Inhibitor of 3 beta-hydroxysteroid dehydrogenase (3-beta-HSD)
Form:Free Base

REVIEW

 Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.

REFERENCES
[1]Komanicky P, Spark RF, Melby JC: Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis. J Clin Endocrinol Metab. 1978 Nov;47(5):1042-51.
[2] Ouschan C, Lepschy M, Zeugswetter F, Möstl E (2012). The influence of trilostane on steroid hormone metabolism in canine adrenal glands and corpora lutea-an in vitro study. Vet Res Commun. 36(1):35-40. PMID 22113849.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H361

Precautionary Statements
P201; P202; P264; P280; P302+P352; P305+P351+P338; P308+P313; P321; P332+P313; P337+P313; P362; P405; P501


Current as of July 17, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Veterinary


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