13647-35-3 Trilostane AKSci J11209
 
 
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  J11209    AKSci Reference Standard
Trilostane
, 99% (HPLC)
 
(4alpha,5alpha,17beta-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
Vetoryl

Structure N/A

IDENTITY
CAS Number:13647-35-3
MDL Number:MFCD00199295
MF:C20H27NO3
MW:329.43
EINECS:237-133-0
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Physical Form:White to off-white powder
Melting Point:257-270°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:DMSO: >=17mg/mL;H 2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Inhibitor of 3 beta-hydroxysteroid dehydrogenase (3-beta-HSD)
Form:Free Base

REVIEW

 Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.

REFERENCES
[1]Komanicky P, Spark RF, Melby JC: Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis. J Clin Endocrinol Metab. 1978 Nov;47(5):1042-51.
[2] Ouschan C, Lepschy M, Zeugswetter F, Möstl E (2012). The influence of trilostane on steroid hormone metabolism in canine adrenal glands and corpora lutea-an in vitro study. Vet Res Commun. 36(1):35-40. PMID 22113849.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H361

Precautionary Statements
P201; P202; P264; P280; P302+P352; P305+P351+P338; P308+P313; P321; P332+P313; P337+P313; P362; P405; P501


Current as of October 20, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use.
Not for human use.

WARNING: Attention California residents: This product can expose you to chemicals including Trilostane, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.


CATEGORIES

 APIs and Bioactives > Veterinary


PubChem