34552-83-5 Loperamide hydrochloride AKSci J10566
 
 
Loading Please Wait...
  J10566    AKSci Reference Standard
Loperamide hydrochloride, >98% (HPLC), powder
 
4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutyramide hydrochloride
IDENTITY
CAS Number:34552-83-5
MDL Number:MFCD00058581
MF:C29H34Cl2N2O2
MW:513.5
EINECS:252-082-4
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:223-229°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: 22mg/mL; H2O: <1mg/mL; EtOH: 27mg/mL
Application(s):Opioid-receptor agonist
Form:HCl salt

REVIEW
 Loperamide is a synthetic anti-diarrheal indicated for the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also it is used for reducing the volume of discharge from ileostomies. Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids.

REFERENCES
[1]Ruppin H. Review: loperamide-a potent antidiarrhoeal drug with actions along the alimentary tract. Aliment Pharmacol Ther. (1987) Jun;1(3): 179-90.
[2] Van Rompay, Jos; Carter, James E. Loperamide hydrochloride. Analytical Profiles of Drug Substances. (1990) 19: 341-65.
[3] Huighebaert S, Awouters F, Tytgat GN. Racecadotril versus loperamide: antidiarrheal research revisited. Dig Dis Sci. (2003) Feb;48(2): 239-50.
[4] Janssen, Paul A. J.; Niemegeers, Carlos J. E. J.; Stokbroekx, Raymond Antoine; Vandenberk, Jan 2,2-Diaryl-4-(4-aryl-4-hydroxypiperidino)butyramides Fr. Demande (1972), FR 2100711 A1 19720428

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501

Current as of April 19, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives >


PubChem