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REVIEW Alendronic acid is a bisphosphonate drug used for osteoporosis and other bone diseases. It inhibits osteoclast-mediated bone resorption. Unlike pyrophosphate, the endogenous regulator of bone turnover to which it is chemically related, alendronate specifically inhibits osteoclastic osteoclastic bone resorption, having no effect on mineralization of bone newly formed by osteoblasts.
Pharmacologically active bisphosphonates and pharmaceuticals containing these substances Belg. (1983), BE 896453 A2 19830801.
Kieczykowski, Gerard R.; Melillo, David G.; Jobson, Ronald B Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof U.S. (1990), US 4922007 A 19900501.
Kieczykowski, Gerard R.; Jobson, Ronald B.; Melillo, David G.; Reinhold, Donald. F.; Grenda, Victor J.; Shinkai, Ichiro Preparation of (4-Amino-1-Hydroxybutylidene)bisphosphonic Acid Sodium Salt, MK-217 (Alendronate Sodium). An Improved Procedure for the Preparation of 1-Hydroxy-1,1-bisphosphonic Acids Journal of Organic Chemistry (1995), 60(25), 8310-12.
Shinkai I, Ohta Y. New drugs--reports of new drugs recently approved by the FDA. Alendronate. Bioorg Med Chem. 1996 Jan;4(1):3-4.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise. They are not sold to individuals. Additional restrictions may apply.
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