66376-36-1, 129318-43-0; 121268-17-5 Alendronic acid AKSci J10298
 
 
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  J10298    AKSci Reference Standard
Alendronic acid
, 98%, powder
 
4-Amino-1-hydroxybutane-1,1-diphosphonic acid




IDENTITY
CAS Number:66376-36-1, 129318-43-0; 121268-17-5
MDL Number:MFCD00868112
MF:C4H13NO7P2
MW:249.1
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%, powder
Physical Form (at 20°C):Solid
Melting Point:233-242°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN1759
Hazard Class:8; Corrosive
Packing Group:III
A hazmat fee may apply, depending on the amount ordered.

BIOLOGICAL INFO
Solubility:H2O

REVIEW

 Alendronic acid is a bisphosphonate drug used for osteoporosis and other bone diseases. It inhibits osteoclast-mediated bone resorption. Unlike pyrophosphate, the endogenous regulator of bone turnover to which it is chemically related, alendronate specifically inhibits osteoclastic osteoclastic bone resorption, having no effect on mineralization of bone newly formed by osteoblasts.

REFERENCES
[1]Pharmacologically active bisphosphonates and pharmaceuticals containing these substances Belg. (1983), BE 896453 A2 19830801.
[2] Kieczykowski, Gerard R.; Melillo, David G.; Jobson, Ronald B Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof U.S. (1990), US 4922007 A 19900501.
[3] Kieczykowski, Gerard R.; Jobson, Ronald B.; Melillo, David G.; Reinhold, Donald. F.; Grenda, Victor J.; Shinkai, Ichiro Preparation of (4-Amino-1-Hydroxybutylidene)bisphosphonic Acid Sodium Salt, MK-217 (Alendronate Sodium). An Improved Procedure for the Preparation of 1-Hydroxy-1,1-bisphosphonic Acids Journal of Organic Chemistry (1995), 60(25), 8310-12.
[4] Shinkai I, Ohta Y. New drugs--reports of new drugs recently approved by the FDA. Alendronate. Bioorg Med Chem. 1996 Jan;4(1):3-4.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of September 29, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Bisphosphonates


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