58909-39-0 Thiotriazinone AKSci C823
 
 
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  C823    AKSci Bulk Reagent
Thiotriazinone, 98% (HPLC)
 
Tetrahydro-2-methyl-3-thioxo-1,2,4-triazine-5,6-dione
1,2,4-Triazin-2-methyl-6-hydroxy-3-thio-5-one
IDENTITY
CAS Number:58909-39-0
MDL Number:MFCD00185756
MF:C4H5N3O2S
MW:159.17
EINECS:261-490-1
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:245°C (dec.)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Side chain used in the preparation of beta-lactam and cephems (e.g. Ceftriaxone for study and applications as antibacterial agents and human leukocyte elastase inhibitors.

REFERENCES
[1]Lambert PA, Conway BR. Pharmaceutical quality of ceftriaxone generic drug products compared with Rocephin. J Chemother. 2003;15(4):357-68.
[2] Tamilselvi, A.; Mugesh, Govindasamy Interaction of heterocyclic thiols/thiones eliminated from cephalosporins with iodine and its biological implications, Bioorganic & Medicinal Chemistry Letters (2010), 20(12), 3692-3697.
[3] Shah, Shrenik K.; Brause, Karen A.; Chandler, Gilbert O.; Finke, Paul E.; Ashe, Bonnie M.; Weston, Hazel; Knight, Wilson B.; Maycock, Alan L.; Doherty, James B. Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins, Journal of Medicinal Chemistry (1990), 33(9), 2529-35.
[4] Kondo, Shinichi; Tsuruoka, Takashi; Iwamatsu, Katsuyoshi; Katano, Kiyoaki; Nakabayashi, Satoru; Ogino, Hiroko; Yoshida, Takashi; Sezaki, Masaji; Preparation of 7-[[(dihydroxypyridonyl)methoxyimino]acetamido]cephemcarboxylates and analogs as antibacterial agents, Eur. Pat. Appl. (1988), EP 289002 A2 19881102.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H319

Precautionary Statements
P264; P280; P305+P351+P338; P337+P313

Current as of April 18, 2024


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⚠️
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