V1656 Fasudil hydrochloride - AK Scientific
 
 
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  Catalog ID # V1656
Fasudil hydrochloride
, 98% (HPLC)
 
Fasudil
5-(1-Homopiperazinyl)sulfonylisoquinoline hydrochloride
1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride
Eril
Fasudil HCl




IDENTITY
CAS Registry #:[105628-07-7]
MDL Number:MFCD00943198
MF:C14H18ClN3O2S
MW:327.83
BRN:5466340
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to almost white powder or crystals
Melting Point:208-215°C
Shipping:Not Regulated for Shipping.

BIOLOGICAL INFO
Solubility:Soluble in water and methanol; Very slightly soluble in ethanol; Insoluble in ether
Application(s):Rho-kinase inhibitor and vasodilator

REVIEW

 RhoA/Rho kinase(ROCK) inhibitor that plays an important role in mediating vasoconstriction and vascular remodeling in the pathogenesis of PH. ROCK induces vasoconstriction by phosphorylating the myosin-binding subunit of myosin light chain (MLC) phosphatase, thus decreasing MLC phosphatase activity and enhancing vascular smooth muscle contraction.

REFERENCES
[1]Nagumo, H., Sasaki, Y., Ono, Y., Okamato, H., Seto, M., and Takuwa, Y. (2000). Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells. American Journal of Physiology. 278: C57-C65.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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CURRENT AS OF: May 26, 2015
Availability
1. In Stock: Order today by 4 PM PT and ships today from San Francisco, CA, USA
2. Backordered: Please contact us for availability.
3. If Bulk (kg) is Backordered, sizes less than 1kg may be available.
4. All prices FOB San Francisco, CA, USA
HazMat
HazMat shipping information is based on IATA/DOT regulations. For reference only.
1. Not Required: Not regulated by IATA/DOT. Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

SDS

 V1656_SDS.pdf

CATEGORIES

 APIs and Bioactives > Protein Kinase Inhibitors

USEFUL LINKS

  PubChem