V0371 Rutaecarpine - AK Scientific
 
 
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  Catalog ID # V0371
Rutaecarpine
, 97% (HPLC)
 
8,13-Dihydro indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one
Rutecarpine




IDENTITY
CAS Registry #:[84-26-4]
MDL Number:MFCD00210551
MF:C18H13N3O
MW:287.32
SPECIFICATIONS & PROPERTIES
Purity:97% (HPLC)
Available Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:White to yellow powder
Melting Point:258-266°C
Long-Term Storage:Store long-term at 2-8°C
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Solubility:DMSO: 18 mg/mL clear yellow solution; H2O: insoluble.
Application(s):Indolopyridoquinazolinone alkaloid

REVIEW

 Rutecarpine (rutaecarpine) is a indolopyridoquinazoline alkaloid isolated from Evodia rutaecarpa (Wu-Chu-Yu) which remains the most popular and multi-purpose herb traditionally used in China for treatment of headache, abdominal pain, postpartum hemorrhage, dysentery and amenorrhea. Rutaecarpine is one of the intriguing indolopyridoquinazoline alkaloids isolated from Wu-Chu-Yu. Rutaecarpine has been shown to have cardiovascular biological effects such as inotropic and chronotropic, vasorelaxant, anti-platelet aggregation and anti-inflammatory effects. Furthermore, it has been reported that rutaecarpine has beneficial effects on some cardiovascular diseases. Rutecarpine has also been shown to be a COX-2 inhibitor.

REFERENCES
[1]Wang GJ, Shan J, Pang PK, Yang MC, Chou CJ, Chen CF. The vasorelaxing action of rutaecarpine: direct paradoxical effects on intracellular calcium concentration of vascular smooth muscle and endothelial cells. J Pharmacol Exp Ther. 1996 Mar;276(3):1016-21.
[2] Sheu JR, Hung WC, Lee YM, Yen MH. Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa. Eur J Pharmacol. 1996 Dec 30;318(2-3):469-75.
[3] Sheu JR, Kan YC, Hung WC, Su CH, Lin CH, Lee YM, Yen MH. The antiplatelet activity of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, is mediated through inhibition of phospholipase C. Thromb Res. 1998 Oct 15;92(2):53-64.
[4] Moon TC, Murakami M, Kudo I, Son KH, Kim HP, Kang SS, Chang HW. A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa. Inflamm Res. 1999 Dec;48(12):621-5.

Risk Description(s)
R25:Toxic if swallowed.

Safety Description(s)
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



Pricing

CURRENT AS OF: August 29, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 V0371_SDS.pdf

CATEGORIES

 APIs and Bioactives > Alkaloids

USEFUL LINKS

  PubChem  @PubMed