REVIEW Rutecarpine (rutaecarpine) is a indolopyridoquinazoline alkaloid isolated from Evodia rutaecarpa (Wu-Chu-Yu) which remains the most popular and multi-purpose herb traditionally used in China for treatment of headache, abdominal pain, postpartum hemorrhage, dysentery and amenorrhea. Rutaecarpine is one of the intriguing indolopyridoquinazoline alkaloids isolated from Wu-Chu-Yu. Rutaecarpine has been shown to have cardiovascular biological effects such as inotropic and chronotropic, vasorelaxant, anti-platelet aggregation and anti-inflammatory effects. Furthermore, it has been reported that rutaecarpine has beneficial effects on some cardiovascular diseases. Rutecarpine has also been shown to be a COX-2 inhibitor.
Wang GJ, Shan J, Pang PK, Yang MC, Chou CJ, Chen CF. The vasorelaxing action of rutaecarpine: direct paradoxical effects on intracellular calcium concentration of vascular smooth muscle and endothelial cells. J Pharmacol Exp Ther. 1996 Mar;276(3):1016-21.
Sheu JR, Hung WC, Lee YM, Yen MH. Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa. Eur J Pharmacol. 1996 Dec 30;318(2-3):469-75.
Sheu JR, Kan YC, Hung WC, Su CH, Lin CH, Lee YM, Yen MH. The antiplatelet activity of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, is mediated through inhibition of phospholipase C. Thromb Res. 1998 Oct 15;92(2):53-64.
Moon TC, Murakami M, Kudo I, Son KH, Kim HP, Kang SS, Chang HW. A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa. Inflamm Res. 1999 Dec;48(12):621-5.
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