Loses 2'-O-butyryl group at pH 8.5. Impurity: =3% N6-monobutyryl-cyclic AMP; =0.5% cyclic AMP and 2'-O-monobutyryl-cyclic AMP
H2O:100mg/mL; DMSO (200mM) or 96% ethanol (25mM).
PKA activator; Phosphodiesterase inhibitor
REVIEW Bucladesine is a cyclic nucleotide derivative, mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor. A cell-permeable cAMP analog which preferentially activates cAMP-dependent protein kinase. The products releaes butyrate due to intracellular and extracellular esterase action. Butyrate was shown to have distinct biological effects. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions.
CURRENT AS OF: October 22, 2016
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The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.
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