[16980-89-5] Bucladesine sodium AKSci U636
 
 
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  Catalog ID # U636
Bucladesine sodium
, 95% (HPLC)
 
Bucladesine
Sodium dibutyryl cAMP
Bucladesine sodium salt
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IDENTITY
CAS Number:[16980-89-5]
MDL Number:MFCD00005843
MF:C18H23N5NaO8P
MW:491.37
EINECS:241-059-4
SPECIFICATIONS & PROPERTIES
Purity:95% (HPLC)
Available Spectra:NMR, LCMS, HPLC
Physical Form:White to off-white to beige powder
Long-Term Storage:Store long-term at -20°C
Note:Loses 2'-O-butyryl group at pH 8.5. Impurity: =3% N6-monobutyryl-cyclic AMP; =0.5% cyclic AMP and 2'-O-monobutyryl-cyclic AMP

BIOLOGICAL INFO
Solubility:H2O:100mg/mL; DMSO (200mM) or 96% ethanol (25mM).
Application(s):PKA activator; Phosphodiesterase inhibitor
Form:Sodium salt

REVIEW

 Bucladesine is a cyclic nucleotide derivative, mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor. A cell-permeable cAMP analog which preferentially activates cAMP-dependent protein kinase. The products releaes butyrate due to intracellular and extracellular esterase action. Butyrate was shown to have distinct biological effects. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P280; P305+P351+P338; P304+P340; P405; P501


Current as of January 16, 2017


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CATEGORIES

 APIs and Bioactives >
 Nucleobases > Nucleotides


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