R853 (+/-)-Verapamil hydrochloride - AK Scientific
 
 
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  Catalog ID # R853
formerly cat #R853
(+/-)-Verapamil hydrochloride
, 98%
 



IDENTITY
CAS Registry #:[152-11-4]
MDL Number:MFCD00055208
MF:C27H39ClN2O4
MW:491.06
EINECS:205-800-5
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white crystalline powder
Melting Point:140-144°C
Long-Term Storage:Store at room temperature
Shipping:Regulated for Shipping
UN #:2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Application(s):Class IV anti-arrhythmia agent

REVIEW

 Verapamil is a phenylalkylamine L-type calcium channel blocker. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and, more recently, cluster headaches and is also an effective preventive medication for migraine. Verapamil has also been used as a vasodilator during cryopreservation of blood vessels. Verapamil's mechanism in all cases is to block voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thus reducing heart rate and blood pressure.

REFERENCES
[1]Basic substituted phenylacetonitriles Belg. (1962), BE 615861 A1 19621001.
[2] Appel, Walter alpha-Isopropyl-alpha-[gamma-(N-methyl-N-homoveratrylamino)propyl]-alpha-(3,4-dimethoxyphenyl)acetonitrile, its determination in biological material and its activity in blood Arzneimittel-Forschung (1962), 12, 562.
[3] Dengel, Ferdinand Method for preparation of basically substituted phenylacetonitriles Ger. (1963), DE 1154810 B 19630926.
[4] Guerrero JR, Martin SS.

Risk Description(s)
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed

Safety Description(s)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



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CURRENT AS OF: February 10, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.
1. Not Required: Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

SDS

 R853_SDS.pdf

CATEGORIES

 APIs and Bioactives > Arrhythmia, Calcium Channel Blockers

USEFUL LINKS

  PubChem  @PubMed