R853 (+/-)-Verapamil hydrochloride - AK Scientific
 
 
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  Catalog ID # R853
(+/-)-Verapamil hydrochloride
, 98%
 



IDENTITY
CAS Registry #:[152-11-4]
MDL Number:MFCD00055208
MF:C27H39ClN2O4
MW:491.06
EINECS:205-800-5
SPECIFICATIONS & PROPERTIES
Purity:98%
Available Spectra:FT-IR, LCMS, HPLC
Physical Form:White to off-white crystalline powder or powder
Melting Point:140-144°C
Long-Term Storage:Store at room temperature
Shipping:Regulated for Shipping
UN #:UN2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Application(s):Class IV anti-arrhythmia agent

REVIEW

 Verapamil is a phenylalkylamine L-type calcium channel blocker. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and, more recently, cluster headaches and is also an effective preventive medication for migraine. Verapamil has also been used as a vasodilator during cryopreservation of blood vessels. Verapamil's mechanism in all cases is to block voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thus reducing heart rate and blood pressure.

REFERENCES
[1]Basic substituted phenylacetonitriles Belg. (1962), BE 615861 A1 19621001.
[2] Appel, Walter alpha-Isopropyl-alpha-[gamma-(N-methyl-N-homoveratrylamino)propyl]-alpha-(3,4-dimethoxyphenyl)acetonitrile, its determination in biological material and its activity in blood Arzneimittel-Forschung (1962), 12, 562.
[3] Dengel, Ferdinand Method for preparation of basically substituted phenylacetonitriles Ger. (1963), DE 1154810 B 19630926.
[4] Guerrero JR, Martin SS.

Risk Description(s)
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed

Safety Description(s)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



Pricing

CURRENT AS OF: October 1, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 R853_SDS.pdf

CATEGORIES

 APIs and Bioactives > Arrhythmia, Calcium Channel Blockers

USEFUL LINKS

  PubChem  @PubMed