REVIEW Catharanthine base is one of the many vinca alkaloids present in Catharanthus roseus. Can be used as a starting material for the synthesis of the anti-tumor drugs vinblastine and vincristine. It also binds to tubulin, with interaction of the indole part of catharanthine being common to its more potent vinca counterparts,
Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 uM. catharanthine . It has also shown to be an acetylcholineesterase receptor inhibitor and an voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. Catharanthine, was shown to stimulate release of amylase from pancreatic fragments and to cause extensive degranulation of pancreatic acinar cells with accumulation of membrane material in the Golgi region. It is indicated that catharanthine activates the physiological pathway controlling amylase release by causing a rise in cytoplasmic Ca2+.
Kutney JP, Bylsma F. Studies on the synthesis of monomeric and dimeric vinca alkaloids. The total synthesis of isovelbanamine, velbanamine, cleavamine, 18 beta-carbomethoxycleavamine, and catharanthine. J Am Chem Soc. 1970 Oct 7;92(20):6090-2.
Williams JA. Catharanthine: a novel stimulator of pancreatic enzyme release. Cell Tissue Res. 1978 Sep 5;192(2):277-84.
Prakash V, Timasheff SN. Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline. Biochemistry. 1991 Jan 22;30(3):873-80.
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