Q790 Desoximetasone - AK Scientific
 
 
Loading Please Wait...
  Catalog ID # Q790
Desoximetasone
, 98% (HPLC)
 
9-Fluoro-11beta,21-dihydroxy-16alfa-methylpregna-1,4-diene-3,20-dione




IDENTITY
CAS Registry #:[382-67-2]
MDL Number:MFCD00083301
MF:C22H29FO4
MW:376.46
EINECS:206-845-3
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:FT-IR, LCMS, HPLC
Physical Form:White powder
Melting Point:212-233°C
Optical Rotation:109° (chloroform)
Long-Term Storage:Store at room temperature
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Application(s):A glucocorticoid antiinflammatory agent

REVIEW

 Desoximetasone is a synthetic topical corticosteroid, used as anti-inflammatory and anti-pruritic agents. It is used for the relief of various skin conditions, including rashes, reducing redness, itching, and irritation - dermatoses, skin allergies, psoriasis. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid.

REFERENCES
[1]Borelli C, Gassmueller J, Fluhr JW, Nietsch KH, Schinzel S, Korting HC. Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay. Skin Pharmacol Physiol. (2008) 21(3): 181-7.
[2] Kircik L, Lebwohl MG, Del Rosso JQ, Bagel J, Stein Gold L, Weiss JS. Clinical study results of desoximetasone spray, 0.25% in moderate to severe plaque psoriasis. J Drugs Dermatol. (2013) Dec;12(12): 1404-10.
[3] Heel, R. C.; Brogden, R. N.; Speight, T. M.; Avery, G. S. Desoxymethasone: a review of its pharmacological properties and therapeutic efficacy in the treatment of dermatoses. Drugs. (1978) 16(4): 302-21.
[4] Hydroxy steroids for coronary spasms (1962), FR M335 19620108.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


Pricing

CURRENT AS OF: September 27, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 Q790_SDS.pdf

CATEGORIES

 APIs and Bioactives > Steroid Hormones

USEFUL LINKS

  PubChem