O918 10-HDA - AK Scientific
 
 
Loading Please Wait...
  Catalog ID # O918
10-HDA
, 97% (GC)
 
Royal Jelly acid
(E)-10-Hydroxy-2-decenoic acid
10-hydroxy-2-decenoic acid
Queen Bee Acid




IDENTITY
CAS Registry #:[14113-05-4]
MDL Number:MFCD00204506
MF:C10H18O3
MW:186.25
SPECIFICATIONS & PROPERTIES
Purity:97% (GC)
Available Spectra:NMR, FT-IR, GCMS, GC
Physical Form:White to off-white crystalline powder or powder
Melting Point:61-65°C
Long-Term Storage:Store long-term at -20°C
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Application(s):An inhibitor of VEGF-induced angiogenesis, cell migration and proliferation

REVIEW

 10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. 10-HDA has longevity-promoting effects in C. elegans at a concentration of 25 µM. It down-regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 µM. 10-HDA also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 µM and 1.5 mM, respectively.

REFERENCES
[1]Kodai, T., Umebayashi, K., Nakatani, T., et al. Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees (Apis mellifera). Chem Pharm Bull 55(10) 1528-1531 (2007).
[2] Honda, Y., Fujita, Y., Maruyama, H., et al. Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PLoS One 6(8) 1-10 (2011).
[3] Wang, J., Ruan, J., Li, C., et al. Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis. Rheumatol Int (2011).
[4] Wang, J., Ruan, J., Li, C., et al. Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis. Rheumatol Int (2011).

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


Pricing

CURRENT AS OF: May 3, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 O918_SDS.pdf

CATEGORIES

 APIs and Bioactives > Natural Products

USEFUL LINKS

  PubChem