O918 10-HDA - AK Scientific
 
 
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  Catalog ID # O918
10-HDA
, 98% (GC)
 
Royal Jelly acid
(E)-10-Hydroxy-2-decenoic acid
10-hydroxy-2-decenoic acid
Queen Bee Acid




IDENTITY
CAS Registry #:[14113-05-4]
MDL Number:MFCD00204506
MF:C10H18O3
MW:186.25
SPECIFICATIONS & PROPERTIES
Purity:98% (GC)
Available Spectra:NMR, FT-IR, GCMS, GC
Physical Form:White to off-white crystalline powder or powder
Melting Point:61-65°C
Long-Term Storage:Store long-term at -20°C
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Solubility:Soluble in chloroform, ethanol, methanol
Application(s):An inhibitor of VEGF-induced angiogenesis, cell migration and proliferation

REVIEW

 10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. 10-HDA has longevity-promoting effects in C. elegans at a concentration of 25 µM. It down-regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 µM. 10-HDA also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 µM and 1.5 mM, respectively.

REFERENCES
[1]Kodai, T., Umebayashi, K., Nakatani, T., et al. Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees (Apis mellifera). Chem Pharm Bull 55(10) 1528-1531 (2007).
[2] Honda, Y., Fujita, Y., Maruyama, H., et al. Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PLoS One 6(8) 1-10 (2011).
[3] Wang, J., Ruan, J., Li, C., et al. Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis. Rheumatol Int (2011).
[4] Wang, J., Ruan, J., Li, C., et al. Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis. Rheumatol Int (2011).

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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CURRENT AS OF: July 27, 2015
Availability
1. In Stock: Order today by 4 PM PT and ships today from San Francisco, CA, USA
2. Backordered: Please contact us for availability.
3. If Bulk (kg) is Backordered, sizes less than 1kg may be available.
4. All prices FOB San Francisco, CA, USA
HazMat
HazMat shipping information is based on IATA/DOT regulations. For reference only.
1. Not Required: Not regulated by IATA/DOT. Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

SDS

 O918_SDS.pdf

CATEGORIES

 APIs and Bioactives > Natural Products

USEFUL LINKS

  PubChem