M363 Dorzolamide HCl - AK Scientific
 
 
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  Catalog ID # M363
Dorzolamide HCl
, 98% (HPLC)
 
Trusopt
Cosopt
4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, hydrochloride




IDENTITY
CAS Registry #:[130693-82-2]
MDL Number:MFCD00884659
MF:C10H16N2O4S3.HCl
MW:360.901
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Physical Form:White to off-white crystalline powder
Melting Point:283-285°C
Optical Rotation:-8° (c=1,MeOH)
Shipping:Not Regulated for Shipping.

BIOLOGICAL INFO
Solubility:DMSO: <1mg/mL; H2O: 14mg/mL; EtOH: <1mg/mL
Application(s):Carbonic anhydrase inhibitor
Form:HCl salt

REVIEW

 A carbonic anhydrase inhibitor. The drug is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.

REFERENCES
[1]Mincione F, Starnotti M, Masini E, Bacciottini L, Scrivanti C, Casini A, Vullo D, Scozzafava A, Supuran CT (2005). Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. Bioorg Med Chem Lett. 15(17):3821-7. PMID 16039853.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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CURRENT AS OF: March 29, 2015
Availability
1. In Stock: Order today by 4 PM PT and ships today from San Francisco, CA, USA
2. Backordered: Please contact us for availability.
3. If Bulk (kg) is Backordered, sizes less than 1kg may be available.
4. All prices FOB San Francisco, CA, USA
HazMat
HazMat shipping information is based on IATA/DOT regulations. For reference only.
1. Not Required: Not regulated by IATA/DOT. Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

SDS

 M363_SDS.pdf

CATEGORIES

 APIs and Bioactives > Ophthalmology, Carbonic Anhydrase Inhibitors

USEFUL LINKS

  PubChem