REVIEW Gadopentetate dimeglumine is a complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid, that is used as a MRI Contrast agent to enhance the image in cranial and spinal MRIs. Abnormal vascularity or disruption of the blood-brain barrier allows accumulation of gadopentetate dimeglumine in lesions such as neoplasms, abscesses, and subacute infarcts. Outside the CNS, gadopentetate dimeglumine rapidly reaches equilibrium in the interstitial compartment and enhances signal in all tissues as a function of delivery and size of the interstitial compartment. This compound has also been found to inhibit human erythrocyte 6-phosphogluconate dehydrogenase.
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