1400-61-9 Nystatin AKSci J10033
 
 
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  J10033    AKSci Reference Standard
Nystatin
 
Fungicidin
Stamycin
Nystavescent
more..
IDENTITY
CAS Number:1400-61-9
MDL Number:MFCD27989284
MF:C47H75NO17
MW:926.95
EINECS:215-749-0
SPECIFICATIONS & PROPERTIES
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 19mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Antifungal; Ionophore
Form:Free Base

REVIEW
 Nystatin exerts its antifungal activity by binding to ergosterol found in fungal cell membranes. Binding to ergosterol causes the formation of pores in the membrane. Potassium and other cellular constituents leak from the pores causing cell death.

REFERENCES
[1]Akaike N, Harata N: Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms. Jpn J Physiol. 1994;44(5):433-73.
[2] Semis R, Nili SS, Munitz A, Zaslavsky Z, Polacheck I, Segal E (2012). Pharmacokinetics, tissue distribution and immunomodulatory effect of intralipid formulation of nystatin in mice. J Antimicrob Chemother. 67(7):1716-21. PMID 22499997.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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⚠️
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CATEGORIES
 APIs and Bioactives > Fungicides


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