I544 Ondansetron - AK Scientific
 
 
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  Catalog ID # I544
Ondansetron
, 98% (HPLC)
 
1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one




IDENTITY
CAS Registry #:[99614-02-5]
MDL Number:MFCD00833882
MF:C18H19N3O
MW:293.36
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:NMR, LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:225-230°C
Long-Term Storage:Store long-term at -20°C
Shipping:Regulated for Shipping
UN #:UN2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Application(s):Serotonin 5-HT3 receptor antagonist

REVIEW

 Ondansetron is a selective serotonin 5-HT3 receptor antagonist. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.

REFERENCES
[1]Ramsook C, Sahagun-Carreon I, Kozinetz CA, Moro-Sutherland D: A randomized clinical trial comparing oral ondansetron with placebo in children with vomiting from acute gastroenteritis. Ann Emerg Med. 2002 Apr;39(4):397-403.
[2] Yilmaz HL, Yildizdas RD, Sertdemir Y: Clinical trial: oral ondansetron for reducing vomiting secondary to acute gastroenteritis in children-a double-blind randomized study. Aliment Pharmacol Ther. 2010 Jan;31(1):82-91. Epub .
[3] Gregory RE, Ettinger DS: 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. A comparison of their pharmacology and clinical efficacy. Drugs. 1998 Feb;55(2):173-89.
[4] Gan TJ: Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same? CNS Drugs. 2005;19(3):225-38.

Risk Description(s)
R25:Toxic if swallowed.

Safety Description(s)
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



Pricing

RELATED PRODUCTS
I544Ondansetron
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CURRENT AS OF: August 30, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 I544_SDS.pdf

CATEGORIES

 APIs and Bioactives > Serotonin Antagonists

USEFUL LINKS

  PubChem