H890 Cyclosporin A - AK Scientific
 
 
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  Catalog ID # H890
Cyclosporin A
, 98% (HPLC)
 
Cyclosporine
Antibiotic S 7481F1




IDENTITY
CAS Registry #:[59865-13-3]
MDL Number:MFCD00274558
MF:C62H111N11O12
MW:1202.6112
BRN:3647785
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:FT-IR, LCMS, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:148-157°C
Optical Rotation:-185.0° - -196.0° (c=0.5, MeOH)
Long-Term Storage:Store long-term at 2-8°C
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Solubility:Soluble in MeOH, EtOH, acetone, ether, CHCl3; slightly soluble in water and saturated hydrocarbons.
Application(s):Immunosuppressant agent

REVIEW

 Cyclosporine binds to cyclophilin. The complex then inhibits calcineurin which is normally responsible for activating transcription of interleukin 2. Cyclosporine also inhibits lymphokine production and interleukin release. In ophthalmic applications, the precise mechanism of action is not known. Cyclosporine emulsion is thought to act as a partial immunomodulator in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca.

REFERENCES
[1]Lichtiger S, Present DH, Kornbluth A, Gelernt I, Bauer J, Galler G, Michelassi F, Hanauer S: Cyclosporine in severe ulcerative colitis refractory to steroid therapy. N Engl J Med. 1994 Jun 30;330(26):1841-5.

Risk Description(s)
R45:May cause cancer.
R60:May impair fertility.
R22:Harmful if swallowed.

Safety Description(s)
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



Pricing

RELATED PRODUCTS
H890Cyclosporin A
Q333Cyclosporine

CURRENT AS OF: September 28, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 H890_SDS.pdf

CATEGORIES

 Amino Acids > Peptides
 APIs and Bioactives > Immunomodulators

USEFUL LINKS

  PubChem