4,6-Dihydroxy-1,3,5-triazine-2-carboxylic acid potassium salt
SPECIFICATIONS & PROPERTIES
White to off-white powder
Store at room temperature
REVIEW Oxonic acid potassium salt is a biochemical modulator in the tegafur/gimeracil/oxonic acid potassium salt combination anticancer drug, which is used for the treatment of advanced gastric cancer and hepatocellular carcinoma. Due to its low permeability, oxonic acid potassium salt stays in the gut, where it reduces the production of 5-fluorouracil by blocking the enzyme orotate phosphoribosyltransferase. Lower 5-fluorouracil levels in the gut result in a lower gastrointestinal toxicity. A similar approach is present in S-1-gimeracil and oteracil potassium used for the treatment of gastric cancer.
Piskala, A.; Gut, J. Nucleic acid components and their analogs. XX. Synthesis of oxonic acid (2,4-dioxo-1,2,3,4-tetrahydro-1,3,5-triazine-6-carboxylic acid) and the acetylation of 2,4-dioxohexahydro-1,3,5-triazines Collection of Czechoslovak Chemical Communications (1962), 27, 1562-71.
Piskala, Alois; Gut, Jiri Potassium 1,2,3,4-tetrahydro-2,4-dioxo-s-triazine-6-carboxylate (potassium 5-aza-orotate). Cyclocondensation of biuret with ethyl potassium oxalate Edited by Townsend, Leroy B.; Tipson, R. Stuart , Nucleic Acid Chem. (1978), 1, 93-5.
Sugi, Mitsuyo; Igi, Masami Preparation of potassium oxonate by oxidation of allantoin using alkali metal hypohalite. Eur. Pat. Appl. (1999), EP 957096 A1 19991117.
Kobayakawa M, Kojima Y.Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies. Onco Targets Ther. 2011;4:193-201.