H746 Esmolol HCl - AK Scientific
 
 
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  Catalog ID # H746
Esmolol HCl
, 98% (HPLC)
 
4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride hydrochloride




IDENTITY
CAS Registry #:[81161-17-3]
MDL Number:MFCD00941432
MF:C16H26ClNO4
MW:331.83
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White or almost white crystalline powder
Melting Point:85-86°C
Long-Term Storage:Store long-term at 2-8°C
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Solubility:H2O: 12 mg/mL
Application(s):beta1 Receptor blocker
Form:HCl salt

REVIEW

 Similar to other beta-blockers, esmolol blocks the agonistic effect of the sympathetic neurotransmitters by competing for receptor binding sites. Because it predominantly blocks the beta-1 receptors in cardiac tissue, it is said to be cardioselective. In general, so-called cardioselective beta-blockers are relatively cardioselective; at lower doses they block beta-1 receptors only but begin to block beta-2 receptors as the dose increases. At therapeutic dosages, esmolol does not have intrinsic sympathomimetic activity (ISA) or membrane-stabilizing (quinidine-like) activity. Antiarrhythmic activity is due to blockade of adrenergic stimulation of cardiac pacemaker potentials. In the Vaughan Williams classification of antiarrhythmics, beta-blockers are considered to be class II agents.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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RELATED PRODUCTS
H746Esmolol HCl
K444Esmolol

CURRENT AS OF: May 30, 2015
Availability
1. In Stock: Order today by 4 PM PT and ships today from San Francisco, CA, USA
2. Backordered: Please contact us for availability.
3. If Bulk (kg) is Backordered, sizes less than 1kg may be available.
4. All prices FOB San Francisco, CA, USA
HazMat
HazMat shipping information is based on IATA/DOT regulations. For reference only.
1. Not Required: Not regulated by IATA/DOT. Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

SDS

 H746_SDS.pdf

CATEGORIES

 APIs and Bioactives > Beta Blockers

USEFUL LINKS

  PubChem