H743 Carbazochrome sodium sulfonate - AK Scientific
 
 
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  Catalog ID # H743
Carbazochrome sodium sulfonate
, 98% (HPLC)
 



IDENTITY
CAS Registry #:[51460-26-5]
MDL Number:MFCD00056013
MF:C10H11N4O5S.Na
MW:322.2729
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:Orange-yellow crystalline powder
Melting Point:227-255°C
Long-Term Storage:Store at room temperature
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Form:Salt

REVIEW

 Carbazochrome, the semicarbazone of adrenochrome, that interacts with a-adrenoreceptors on surface of platelets, which are coupled to Gq protein and initiate PLC IP3/DAG pathway to increase intracellular free calcium concentration with these subsequent actions: Activates PLA2 and induce arachidonic acid pathway to synthese endoperoxides (TxA2, thromboxane A2) and then calcium binds to calmodulin which then binds and activates myosin light-chain kinase, that will enable the myosin crossbridge to bind to the actin filament and allow contraction to begin. This will change platelet's shape and induce release of serotonin, ADP, vWF (Von Willebrand factor), PAF (Platelet-activating factor) to promote further aggregation and adhesion.

REFERENCES
[1]Squadrito F, Altavilla D, Oliaro Bosso S (2000). Double-blind, randomized clinical trial of troxerutin-carbazochrome in patients with hemorrhoids. Eur Rev Med Pharmacol Sci 4 (1-2): 21-4. PMID 11409185.
[2] Basile M, Gidaro S, Pacella M, Biffignandi PM, Gidaro GS (2001). Parenteral troxerutin and carbazochrome combination in the treatment of post-hemorrhoidectomy status: a randomized, double-blind, placebo-controlled, phase IV study. Curr Med Res Opin 17 (4): 256-61. PMID 11922398.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


Pricing

RELATED PRODUCTS
H743Carbazochrome sodium sulfonate
K175Carbazochrome

CURRENT AS OF: May 30, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 H743_SDS.pdf

CATEGORIES

 APIs and Bioactives > Antihemorrhagics

USEFUL LINKS

  PubChem