H578 9,11b-Epoxy-17,21-dihydroxy-16a-methyl-9b-pregna-1,4-diene-3,20-dione - AK Scientific
 
 
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  Catalog ID # H578
9,11b-Epoxy-17,21-dihydroxy-16a-methyl-9b-pregna-1,4-diene-3,20-dione
, 98% (HPLC)
 



IDENTITY
CAS Registry #:[24916-90-3]
MDL Number:MFCD07782140
MF:C22H28O5
MW:372.4547
EINECS:246-529-2
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Physical Form:White crystalline powder
Melting Point:230-235°C
Density:1.32
Long-Term Storage:Store at room temperature
Shipping:Not Regulated for Shipping

REVIEW

 9,11b-Epoxy-17,21-dihydroxy-16a-methyl-9b-pregna-1,4-diene-3,20-dione is a key intermediate used in the synthesis of various biologically active corticosteroids, e.g. mometasone and furoate.

REFERENCES
[1]Fu, Xiaoyong; Tann, Chou-Hong; Thiruvengadam, T. K. Process Improvements in the Synthesis of Corticosteroid 9,11beta-Epoxides. Organic Process Research & Development. (2001) 5(4): 376-382.
[2] Li, Ping; Lu, Junrui; Li, Xia; Guo, Jianlong. Method for preparation of Mometasone furoate intermediate having hydroxy group at C21-position. Faming Zhuanli Shenqing Gongkai Shuomingshu. (2006) CN 1810825 A 20060802.
[3] Cherniak, Simon; Cyjon, Rosa; Ozer, Ilana; Nudelman, Igor. Process for the preparation of 17-desoxy-corticosteroids. PCT Int. Appl. (2012) WO 2012011106 A1 20120126.
[4] Steroids (1962), GB 912379 19621205

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


Pricing

CURRENT AS OF: May 6, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 H578_SDS.pdf

CATEGORIES

 APIs and Bioactives > Steroid Hormones

USEFUL LINKS

  PubChem