G787 Clofarabine - AK Scientific
 
 
Loading Please Wait...
  Catalog ID # G787
Clofarabine
, 98% (HPLC)
 
(2R,3R,4S,5R)-5-(6-Amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
2-chloro-2''-arabino-fluoro-2''-deoxyadenosine
Clolar
Evoltra




IDENTITY
CAS Registry #:[123318-82-1]
MDL Number:MFCD00871077
MF:C10H11ClFN5O3
MW:303.68
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White powder
Melting Point:228-233°C
Long-Term Storage:Store long-term at 2-8°C
Shipping:Regulated for Shipping
UN #:2811
Hazard Class:6.1
Packing Group:III
Note:Manual review is required before order is released.

BIOLOGICAL INFO
Solubility:DMSO: 61mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase
Form:Free Base

REVIEW

 Clofarabine is metabolized intracellularly to the active 5''-monophosphate metabolite by deoxycytidine kinase and 5''-triphosphate metabolite by mono- and di-phospho-kinases. This metabolite inhibits DNA synthesis through an inhibitory action on ribonucleotide reductase, and by terminating DNA chain elongation and inhibiting repair through competitive inhibition of DNA polymerases. This leads to the depletion of the intracellular deoxynucleotide triphosphate pool and the self-potentiation of clofarabine triphosphate incorporation into DNA, thereby intensifying the effectiveness of DNA synthesis inhibition. The affinity of clofarabine triphosphate for these enzymes is similar to or greater than that of deoxyadenosine triphosphate. In preclinical models, clofarabine has demonstrated the ability to inhibit DNA repair by incorporation into the DNA chain during the repair process. Clofarabine 5''-triphosphate also disrupts the integrity of mitochondrial membrane, leading to the release of the pro-apoptotic mitochondrial proteins, cytochrome C and apoptosis-inducing factor, leading to programmed cell death.

REFERENCES
[1]Pession A, Masetti R, Kleinschmidt K, Martoni A: Use of clofarabine for acute childhood leukemia. Biologics. 2010 Jun 24;4:111-8.
[2] Harned TM, Gaynon PS: Treating refractory leukemias in childhood, role of clofarabine. Ther Clin Risk Manag. 2008 Apr;4(2):327-36.
[3] Lech-Maranda E, Korycka A, Robak T: Clofarabine as a novel nucleoside analogue approved to treat patients with haematological malignancies: mechanism of action and clinical activity. Mini Rev Med Chem. 2009 Jun;9(7):805-12.
[4] Larson ML, Venugopal P: Clofarabine: a new treatment option for patients with acute myeloid leukemia. Expert Opin Pharmacother. 2009 Jun;10(8):1353-7.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.



Pricing

RELATED PRODUCTS
E997Cladribine
G787Clofarabine

CURRENT AS OF: May 1, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 G787_SDS.pdf

CATEGORIES

 APIs and Bioactives > Chemotherapeutics
 Nucleobases > Nucleosides

USEFUL LINKS

  PubChem